Tissue scaffold

摘要

A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues such as bone, ligament and tendon, which may fabricated into medical devices suitable for use in the treatment of injuries and maladies such as rotator cuff injuries, periodontal disease and hernia.

主权项

1. A three-dimensional tissue comprising a biocompatible scaffold, a continuous membrane of bioabsorbable material encasing the scaffold, and extracellular matrix deposited directly by cells onto the scaffold, wherein the three-dimensional tissue comprises no living cells, wherein the bioabsorbable material is selected from at least one member of the group consisting of glycolide, lactide, trimethylene carbonate, dioxanone, caprolactone, alkylene oxides, ortho esters, polymers and copolymers therof, collagen, hyaluronic acids, alginates, and mixtures thereof.