“VACINA PARA USO NA PROTEÇÃO DE AVES DOMÉSTICAS CONTRA A BRONQUITE INFECCIOSA, MÉTODO PARA A PREPARAÇÃO DA MESMA, E, USO DA CEPA BEAUDETTE DE IBV”

摘要

The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.