Surface modified multilayered nanostructures for dermal delivery

摘要

Dermal delivery is best suited for the various skin diseases or disorders. However, the stratum corneum limits the permeation of number of suitable pharmaceutical agents for dermal delivery. Certain embodiments of the present invention include surface modified multilayered nanostructures. The modification was completed by using fatty acids enabling delivery of a significant amount of one or more pharmaceutical agent(s) into deeper layers of the epidermis and dermis to treat skin diseases or disorders. Each active pharmaceutical agent can be encapsulated into the separate layers of the nanostructures.

主权项

1. A composition for dermal delivery of at least one pharmaceutical agent through a stratum corneum of a subject, comprising each of the at least one a pharmaceutical agent admixed with at least one layer of polymeric nanostructures, wherein the at a least one layer of polymeric nanostructures includes an outer layer with an outer surface covalently bonded by at least one spacer linked to at least one skin-permeating fatty acid such that the at least one spacer linked to the at least one skin-permeating fatty acid extends from the outer surface of the outer layer of polymeric nanostructures to facilitate penetration of the composition through the stratum corneum of the subject, wherein the at least one spacer linked to the at least one fatty acid is a fatty acid-PEG-succinimidyl glutamate ester structure.