Process for producing fluorinated alcohols

摘要

The present invention is directed to a process for preparation of fluorinated alcohols of Formula (I)
RfCH2CH2OH  (I)
by contacting a fluorinated iodide with an alkyl vinyl ether in the presence of an initiator and a base to generate an intermediate hemi-acetal or aldehyde or a mixture thereof, followed by hydrogenation of the hemi-acetal of Formula (II)
RfCH2CH(OCxH2x+1)m(OH)p  (II)
or aldehyde of Formula (III)
RfCH2CHO  (III)
or a mixture thereof, to yield a compound of Formula (I).

主权项

1. A process for preparation of a compound of Formula (I)
RfCH2CH2OH  (I)wherein
Rf is linear or branched CnF2n+1 optionally interrupted by at least one oxygen, CH2, CH2CH2, or CH2CF2; and n is 1 to 10;comprising
a) contacting a compound of formula RfI, wherein Rf is defined as above, with an alkyl vinyl ether containing 1 to 4 carbons in the alkyl, in the presence of an initiator and a base to generate a mixture of intermediates comprising an hemi-acetal of Formula (II) and an aldehyde of Formula (III)
RfCH2CH(OCxH2x+1)m(OH)p  (II)RfCH2CHO  (III) wherein Rf is defined as above, m is 0 to 1; and p is 1 to 2; provided that m+p is 2; and x is 1 to 4; and b) hydrogenating, under acidic conditions, the mixture comprising the hemi-acetal of Formula (II) and aldehyde of Formula (III) to yield a compound of Formula (I).