| 发明名称 | 2-cyanophenylboronic acid or ester thereof in which impurities are decreased, and production method thereof | ||
| 摘要 | A method for producing high-purity 2-cyanophenylboronic acid, characterized by reacting benzonitrile, lithium 2,2,6,6-tetramethylpiperidide, and trialkoxyborane, adding an aqueous acidic solution to a reaction solution containing the obtained 2-cyanophenylboronic acid, carrying out a contact treatment at a pH of below 7 in the presence of a water-immiscible organic solvent, and then obtaining the 2-cyanophenylboronic acid from the organic layer. | ||
| 申请公布号 | US8865942(B2) | 申请公布日期 | 2014.10.21 |
| 申请号 | US200712226747 | 申请日期 | 2007.04.11 |
| 申请人 | Tosoh Finechem Corporation | 发明人 | Nakamura Shinichiro |
| 分类号 | C07F5/02 | 主分类号 | C07F5/02 |
| 代理机构 | Wenderoth, Lind & Ponack, LLP. | 代理人 | Wenderoth, Lind & Ponack, LLP. |
| 主权项 | 1. A method for producing high-purity 2-cyanophenylboronic acid, said method comprising: reacting benzonitrile, lithium 2,2,6,6-tetramethylpiperidide, and trialkoxyborane to obtain 2-cyanophenylboronic acid, adding a reaction solution containing the obtained 2-cyanophenylboronic acid to an aqueous acidic solution, carrying out a contact treatment at a pH of below 7 in the presence of a water-immiscible organic solvent, and then obtaining the high-purity 2-cyanophenylboronic acid from the organic layer. | ||
| 地址 | Yamaguchi JP | ||