Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging

摘要

The present invention relates to dietary compositions comprising reduced level of methionine, tryptophan, all amino acids, or protein, dietary compositions comprising glycerol as a substitute for monosaccharides, disaccharides, and polysaccharides, and hypocaloric or calorie free diets with reduced level of energy, carbohydrates, or protein. Also disclosed are methods of using these compositions and diets, as well as fasting, to protect subjects against chemotherapy, radiotherapy, oxidative stress, or aging.

主权项

1. A method of protecting an animal or human against chemotherapy or radiotherapy, comprising:
administering to an animal or human, prior to chemotherapy or radiotherapy, a diet capable of providing nutrition while providing no more than 11 kcal energy per kg body weight of the animal or human per day, and no more than 0.4 g protein per kg body weight of the animal or human per day, thereby protecting the animal or human against chemotherapy, radiotherapy, oxidative stress, or aging, wherein no more than half of the energy is in carbohydrates if carbohydrates are present in the diet.