PROCESSO PARA O ISOLAMENTO E A PURIFICAÇÃO DE UMA PROTEÍNA-ALVO LIVRE DE PROTEÍNA PRÍON (PrPsc)

摘要

A process for isolation and purification of a target protein by chromatography comprising the steps of
- contacting a potentially PrP SC -contaminated sample comprising a target protein with a multimodal chromatographic material;
- setting buffer conditions so that the target protein is bound to the multimodal chromatographic material and PrP SC are eluted;
followed by elution of the target protein.