Wet formulations of aripiprazole

摘要

The invention encompasses wet granulation pharmaceutical compositions of aripiprazole, methods of making tablets from the compositions, and tablets of the wet granulation pharmaceutical composition.

主权项

1. A method of making an aripiprazole pharmaceutical composition by wet granulation comprising:
providing a mixture of aripiprazole, at least one diluent, at least one tablet binder, and water; blending the mixture to obtain a wet granulate; drying the wet granulate at a temperature of less than 70° C. to obtain a dried granulate; and milling the dried granulate to obtain the pharmaceutical composition comprising a milled dried granulate, with the proviso that the wet granulate is not milled prior to drying, wherein the aripiprazole is anhydrous aripiprazole.