| 摘要 |
Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.; |
| 主权项 |
1. A method for modulating an activity of an androgen receptor comprising contacting an androgen receptor with a compound of Formula (II): wherein: R1 is NO2 or CN; R2 is selected from among F, Cl, Br, I, SRA, NO2, and CF3; R3and R4 are each independently selected from hydrogen, F, Cl, ORA, an optionally substituted C1-C4 alkyl, and CF3; R5 is hydrogen; R10 is hydrogen; R6a and R7a are each independently hydrogen or an optionally substituted C1-C6 alkyl; R9 is selected from an optionally substituted C1-C8 alkyl, C1-C8 heteroalkyl, CH(RD)ORA, CH(RD)NRARB, and CORA; R12 and R13 are each independently selected from hydrogen, F, Cl, ORA, and (CH2)mRC; RA is hydrogen; RB is hydrogen; RC is selected from an optionally substituted aryl and an optionally substituted heteroaryl that is optionally with a substituent selected from F, Cl, Br, I, CN, ORA, NO2, NRARB, SRA, SORA, SO2RA, an optionally substituted C1-C4 alkyl, CF3, and an optionally substituted C1-C4 heteroalkyl; RD is hydrogen or CF3; Z is CRARB; n is 0; and in is 1 or 2, or a pharmaceutically acceptable salt thereof. |
