Method and apparatus for assessing neural activation

摘要

Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

主权项

1. A method for assessing neural activation of a brain, comprising:
sensing one or more bioelectrical signals from one or more electrodes in contact with or proximate the brain; measuring the amplitude of the one or more bioelectrical signals over a period of time; calculating a plurality of variance values from the amplitude of the one or more bioelectrical signals, each of the variance values of the plurality corresponding to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values of the plurality of variance values; and assessing the relative level of neural activation of an area of the brain based on the plurality of variance values, wherein the area of the brain is assessed to have a higher level of neural activation when the variance is higher as compared to the level of neural activation when the variance is lower and wherein sensing, measuring, calculating, and assessing are each performed at least in part by control circuitry; wherein assessing the relative level of neural activation of the area of the brain comprises estimating the functional synaptic volume of the area of the brain.