NOVEL PREPARATION METHOD OF METABOLITES OF FLUVASTATIN USING BACTERIAL CYTOCHROME P450 AND COMPOSITION THEREFOR

摘要

The present invention relates to a method for producing metabolites from fluvastatin using bacterial cytochrome P450 and a composition therefor and, more specifically, to a composition for manufacturing a 5-hydroxyl product and a 6-hydroxyl product from fluvastatin containing bacterial cytochrome P450 BM3(CYP102A1), a mutant of the CYP102A1, and the chimera of the mutant of the CYP102A1, a kit, and a production method thereof.