| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to organic chemistry, namely to a new compound of formulaor its pharmaceutically acceptable salt, wherein Rrepresents (C-C)alkyl; an oxodihydropyridyl ring in the formula is optionally substituted by 1-3 groups optionally specified in fluorine, (C-C)alkyl, hydroxy(C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkylalkyl, halo(C-C)alkyl and (C-C)alkoxy(C-C)alkoxy; Rrepresents (C-C)alkyl, phenyl, or tetrahydropyranyl optionally substituted by a group in the number of up to 1 independently specified in fluorine, hydroxy(C-C)alkyl and (C-C)cycloalkyl; Ris specified in (C-C)alkyl optionally substituted by groups in the number of up to 3 independently specified in fluorine, cyano, R, RO-, (R)N-, RC(=O)NR-, (R)NC(=O)-, ROC(=O)NR-, RS(=O)NR- and oxadiazolyl optionally substituted by (C-C)alkyl; Rindependently represents H or (C-C)alkyl. Also, the invention refers to a method of treating an individual by using the above compound, a method of inhibiting 11?-HSD1, and a compound-based pharmaceutical composition.EFFECT: there are prepared new compounds effective in treating the diseases related to 11?-HSD1 activity or expression.15 cl, 6 tbl, 101 ex |
