| 摘要 |
<p>The present invention relates to fast dissolving tablets containing entecavir, which is used for treating hepatitis B virus infection, or a pharmaceutically acceptable salt of the entecavir and a method for manufacturing the fast dissolving tablets. The fast dissolving tablets according to the present invention are manufactured by mixing a whole substance, which is prepared by mixing an active ingredient entecavir or a pharmaceutically acceptable salt thereof with a diluting agent water soluble sugar alcohol, with a disintegrating agent and the pharmaceutically acceptable salt afterward, thereby having an equal content of whole drug and long term stability. Also, the manufacture of the fast dissolving tablets according to the present invention is easy by using a wet process, and the fast dissolving tablets are easy to take since the dosage required to the patients is markedly low by reducing the total weight when compared with the conventional preparations containing the entecavir as an active ingredient. Additionally, the fast dissolving tablets are rapidly dissolved when taking so that oral administration is possible without a drink, and the compliance of a patient is increased by improving the characteristic bitter taste and texture, thereby being useful as fast dissolving tablets for treating hepatitis B virus infection.</p> |
