| 摘要 |
The present disclosure is generally directed to neuroactive 17(20)-Z-vinylcyano-substituted compound of Formula (I) and (II), as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. |
| 主权项 |
1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof;wherein:
R1 is H; R2 is ═O, H, or ORa, where Ra is selected from H, optionally substituted C1-C4 alkyl, or optionally substituted aryl, with the proviso that when R2 is ═O, R8 is not present; R3 is H, optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkene, optionally substituted C2-C4 alkyne, or optionally substituted aryl; R4 and R5 are each independently selected from H and unsubstituted C1-C4 alkyl; R6 is H, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy; R7 is H, optionally substituted C1-C4 alkoxy, or an optionally substituted morpholinyl ring; R8, when present, is H or optionally substituted C1-C4 alkyl; and, - - - denotes an optional, additional C—C bond, resulting in either a C═C bond between C4-C5 or C5-C6, with the proviso that when present, the C5—H substituent is not present. |
