发明名称 |
Class I Anti-CEA Antibodies and Uses Thereof |
摘要 |
The present invention provides compositions and methods of use of humanized, chimeric or human Class I anti-CEA antibodies or fragments thereof, preferably comprising the light chain variable region CDR sequences SASSRVSYIH (SEQ ID NO:1); GTSTLAS (SEQ ID NO:2); and QQWSYNPPT (SEQ ID NO:3); and the heavy chain variable region CDR sequences DYYMS (SEQ ID NO:4); FIANKANGHTTDYSPSVKG (SEQ ID NO:5); and DMGIRWNFDV (SEQ ID NO:6). The Class I anti-CEA antibodies or fragments are useful for treating diseases, such as cancer, wherein the diseased cells express CEACAM5 and/or CEACAM6 antigens. The Class I anti-CEA antibodies or fragments are also of use for interfering with specific processes, such as metastasis, invasiveness and/or adhesion of cancer cells, or for enhancing sensitivity of cancer cells to cytotoxic agents and have favorable effects on the survival of subjects with cancer. |
申请公布号 |
US2014308278(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
US201414289066 |
申请日期 |
2014.05.28 |
申请人 |
Immunomedics, Inc. |
发明人 |
Hansen Hans J.;Chang Chien-Hsing;Goldenberg David M. |
分类号 |
C07K16/30;A61K49/22;A61K49/00;A61K51/10;A61K47/48 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
1. A kit comprising: (i) a chimeric, humanized or human Class I anti-CEA antibody or antigen-binding fragment thereof, comprising the light chain variable region CDR (complementarity determining region) sequences SASSRVSYIH (SEQ ID NO:1); GTSTLAS (SEQ ID NO:2); and QQWSYNPPT (SEQ ID NO:3); and heavy chain variable region CDR sequences DYYMS (SEQ ID NO:4); FIANKANGHTTDYSPSVKG (SEQ ID NO:5); and DMGIRWNFDV (SEQ ID NO:6); and (ii) one or more containers. |
地址 |
Morris Plains NJ US |