| 主权项 |
1. A method of treating an alcohol use disorder in a human comprising administering to a human in need of such treatment an effective amount of a compound of the formula:or a pharmaceutically acceptable salt thereof;
wherein A is R1 is fluoro or chloro; R2a and R2b are each hydrogen or are each fluoro; R3 is hydrogen, methyl, hydroxymethyl, or (C1-C3) alkoxymethyl; R4 is selected from the group consisting of fluoro, chloro, cyano, cyanomethyl, (C1-C3) alkyl, cyclopropyl, hydroxymethyl, methoxy, cyclopropylmethoxy, aminocarbonylmethoxy, (C1-C3) alkoxymethyl, cyclopropyloxymethyl, cyclopropylmethoxymethyl, 1-hydroxy-1-methylethyl, aminocarbonyloxymethyl, methylaminocarbonyloxymethyl, dimethylaminocarbonyloxymethyl, aminocarbonyl, aminocarbonylmethyl, —CH2—NR5R6, hydroxyimine, methoxyimine, morpholin-4-yl, morpholin-4-ylmethyl, Ar1, —CH2Ar1, tetrahydrofuran-2-yl, 3-oxomorpholin-4-ylmethyl, 2-oxopyrrolidin-1-ylmethyl, and 2-oxopiperidin-1-ylmethyl; R4′ is selected from the group consisting of fluoro, chloro, cyano, cyanomethyl, (C1-C3) alkyl, cyclopropyl, hydroxymethyl, methoxy, methoxymethyl, aminocarbonyloxymethyl, methylaminocarbonyloxymethyl, dimethylaminocarbonyloxymethyl, methylcarbonyl, aminocarbonyl, methylaminocarbonyk_dimethylaminocarbonyl, —NR5′R6, —CH2—NR5′R6, morpholin-4-yl, morpholin-4-ylmethyl, Ar2, —CH2Ar2, 3,3-difluoroazetidin-1-ylmethyl, pyrrolidin-1-ylmethyl, 1-aminocyclopropyl, 1-methylaminocyclopropyl, and 1-dimethylaminocyclopropyl; R5 is hydrogen, C1-C3 alkyl, cyanomethyl, —C(O)CH3, or aminocarbonylmethyl; R5′ is hydrogen, C1-C4 alkyl, cyclopropyl, hydroxyethyl, methoxyethyl, —C(O)CH3, or —C(O)O(C1-C3) alkyl; R6 is hydrogen or methyl; R7 is hydrogen, fluoro, chloro, methyl, hydroxymethyl, or methoxy; Ar1 is a moiety selected from the group consisting of imidizol-1-yl, imidizol-2-yl, 2-methylimidizol-1-yl, pyrazol-1-yl, 1,2,3-triazol-1-yl; 1,2,3-triazol-2-yl; 1,2,4-triazol-1-yl, isoxazol-3-yl, oxazol-5-yl, and 3-methyl-1,2,4-oxadiazol-5-yl; and Ar1 is a moiety selected from the group consisting of imidizol-1-yl, imidizol-2-yl, 2-methylimidizol-1-yl, 1-methylimidizol-2-yl, and 1,2,4-triazol-3-yl. |
