| 摘要 |
Among other things, the present invention provides modular systems for designing, characterizing, and/or manufacturing soluble lipidated ligand agents. In general, such soluble lipidated active agents include a ligand entity, a lipid entity, and, in some embodiments, an optional linker component. In some aspects, the present invention defines relevant structural and/or functional parameters of each of these components and/or of their linkage to one another, thereby enabling appropriate selection of components to assemble active agents for any given target of interest. In some embodiments, the invention defines and/or provides sets of such components that include appropriate reactive moieties for linking components to one another, for example using simple and/or robust chemistries, so that selected components are readily linked to one another in the production of agents as described. |
