TARGETED IDENTIFICATION OF IMMUNOGENIC PEPTIDES

摘要

PROBLEM TO BE SOLVED: To provide a simple method for the identification of immunogenic peptides derived from regions of self-proteins, and other proteins and molecules, which are involved in the binding interactions with polyclonal and monoclonal antibodies.SOLUTION: A method for synthesizing an immunogenic peptide from a self-protein comprises the steps of: identifying one or more peptide sequences of a self-protein that are directly or indirectly involved with antibody-binding; subjecting the one or more peptide sequences to analysis by using an algorithm that identifies sequences suspected of being immunogenic; screening all peptide fragments from the one or more peptide sequences; and identifying an immunogenic peptide of the protein fragment. The antibody-binding interaction may be polyclonal or monoclonal.