| 摘要 |
Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or as a treatment for various CNS-related disorders in which the monoamine transport and related systems are implicated. |
| 主权项 |
1. A compound having formula I: or a pharmaceutically acceptable derivative or salt thereof; wherein; p is 0 to 5; R is W is H, OH, or NHRo; R0 is H or C1-18 alkyl; R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR2, C5-10 cycloalkyl, C2-18 alkenyl, —OH, —NO2, —NHR2, or —OR2; R2 is C1-8 alkyl, C5-6 cycloalkyl, or C2-8 alkenyl; R3 is F, Cl, Br, OR4, NO2, NHR4, NH(CO)R4, N(CO)OR4, SO2NH2, or N(R4)2; the dashed line is an optional bond; T is CH or N; r is 0 to 5; X, Y, and Z are each independently CR4, CR42, C—NHR4, C═O, S, N, or NR4; and R4 is H or C1-g alkyl. |
