| 发明名称 |
Derivatisation of Erythropoietin (EPO) |
| 摘要 |
The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds. |
| 申请公布号 |
US2014309407(A1) |
申请公布日期 |
2014.10.16 |
| 申请号 |
US201414313897 |
申请日期 |
2014.06.24 |
| 申请人 |
LIPOXEN TECHNOLOGIES LIMITED |
发明人 |
Jain Sanjay;Laing Peter;Gregoriadis Gregory;Rumpf Norbert Oskar |
| 分类号 |
C07K14/575 |
主分类号 |
C07K14/575 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing a polysaccharide derivative of erythropoietin (EPO), comprising: reacting the polysaccharide with an amine group of an internal amino acid side chain of EPO, wherein the polysaccharide is anionic and comprises between 2 and 125 saccharide units and wherein the EPO is derivatised by the polysaccharide at the reducing terminal unit of the polysaccharide. |
| 地址 |
London GB |
