发明名称 |
Diether based biodegradable cationic lipids for siRNA delivery |
摘要 |
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA. |
申请公布号 |
AU2013240051(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
AU20130240051 |
申请日期 |
2013.03.25 |
申请人 |
SIRNA THERAPEUTICS, INC. |
发明人 |
STANTON, MATTHEW G.;BUDZIK, BRIAN W.;COLLETTI, STEVEN L. |
分类号 |
A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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