Antisense Modulation of Apolipoprotein B Expression

摘要

Methods for the rapid and long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated apolipoprotein B are provided. WO 2006/020676 PCT/US2005/028342 Figure 1 MAD25 MD25 MD25 APOB-1 00 LDL T,,tal CholesterolI p= 0.0002 p= 0.0002 p< 0.0001 2O o0 0 0 0 0 0 0 0 0 a)0 0 -0 00 0 C 0 0 0 -00 -100 00 0 Trough AUC (pg*hr/mL)