NOVEL PHARMACEUTICAL FORMULATION CONTAINING BIGUANIDE AND THIAZOLIDINEDIONE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical dosage form that enables controlled or sustained release in combination with an antidiabetic and a thiazolidinedione derivative.SOLUTION: A pharmaceutical dosage form comprises a core made by surrounding an antidiabetic such as HCL methoxylsine with a semipermeable membrane for controlled release, with the core seal-coated with an immediate release coating agent, immediately dispersed or dissolved in water and comprising HCL metformin (thiazolidinedione derivative).