发明名称 |
Ex Vivo Expansion of Human Hematopoietic Stem Cells |
摘要 |
Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for the expansion of human HSCs in a defined medium. Methods of administering expanded human HSCs to and individual are provided as well as methods of treating an individual by administering certain growth factors and cytokines. |
申请公布号 |
US2014308747(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
US201314077776 |
申请日期 |
2013.11.12 |
申请人 |
Whitehead Institute for Biomedical Research |
发明人 |
Zhang ChengCheng;Lodish Harvey |
分类号 |
C12N5/0789 |
主分类号 |
C12N5/0789 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Cambridge MA US |