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1. A gambogenic acid derivative, characterized in that said gambogenic acid derivative is represented by Formula (I) or Formula (II) as follows:wherein:
A is —CO— or —HC(OH)—; R2 is selected from any one of the substituted groups as follows: hydrogen, straight chain or branched chain C1 to C10 alkyl group, C3 to C8 cycloalkyl group, aromatic group or aromatic group substituted by C1 to C10 alkyl, heteroaryl group, and acyl group substituted by C1 to C10 alkyl or acyl group substituted by aromatic group; R3 is selected from any one of the substituted groups as follows: hydrogen, acyl group substituted by C1 to C10 alkyl or aryl group substituted by aromatic group; R is selected from any one of the substituted groups as follows: hydrogen, straight chain or branched chain C1 to C10 alkyl group, C3 to C8 cycloalkyl group, straight chain or branched chain C2 to C10 alkenyl group or C3 to C8 cycloalkenyl group, phenyl group or phenyl group substituted by C1 to C10 alkyl group, C2 to C6 alkynyl group, nucleophiles containing secondary amine group including straight chain or branched chain alkyl amino group, straight chain or branched chain alkenyl amino group; aromatic or aromatic alkylamino group, the amine obtained by addition of chain alkynyl amine group and α,β-unsaturated ketones; R1 is selected from: wherein R4 is selected from the group consisting of any one of the following: hydrogen, straight chain or branched chain C1 to C10 alkyl group, or alkyl group containing optionally 1 to 3 substituted groups including oxygen group, halogen, C1 to C10 alkoxy group, acyloxy group, C1 to C10 alkoxycarbonyl group, aryloxy group; C3-C8 cycloalkyl group, C1 to C10 alkyl group substituted by 1, 2 or 3 heteroatoms; alkylaryl group including C1 to C10 alkyl group substituted by aromatic group and C1 to C10 alkyl group optionally substituted by 1 to 3 substituted aromatic groups including acyl group, —OCH2O—, halogen, haloalkyl group, aryl group, C3 to C8 cycloalkyl group, C1 to C10 alkyl group, hydroxyl group, acyloxy group, C1 to C10 alkoxy group; heteroarylalkyl group including C1 to C10 alkoxy group substituted by heteroaryl group, and C1 to C10 alkyl group optionally substituted by any heteroaryl group including heteroaryl group, C1 to C10 alkyl group, aralkyl group, C3 to C8 cycloalkyl group, C1 to C10 alkoxycarbonyl group, carbamoyl group, aromatic group and C1 to C6 amide group; straight chain or branched chain C2 to C10 alkenyl group or alkenyl group including optionally 1 to 3 substituted groups including oxygen group, halogen, aromatic ring group, aralkyl group, C1 to C10 alkoxy group, acyloxy group, amide group, C1 to C6 amine acyl group, C1 to C10 alkoxy group and C1 to C10 heteroalkyl group including 1, 2 or 3 heteroatoms; C4 to C10 cycloalkenyl, C4 to C10 alkynyl group, or alkynyl group including optionally 1 to 3 substituted group including oxygen group, halogen, aromatic ring group, aralkyl group, C1 to C10 alkoxy group, acyloxy group, amide group, C1 to C6 acyl group, C1 to C10 alkoxy group, aryloxy group and C1 to C10 heteroalkyl group including optionally 1, 2 or 3 heteroatoms; R5 and R6 are independently selected from any one of the substituted groups as follows: hydrogen; straight chain or branched C1 to C10 alkyl group or C1 to C10 alkyl group containing optionally 1 to 3 substituted groups including oxygen group, halogen, C1 to C10 alkoxy group, acyloxy group, C1 to C10 alkoxyacyl group, aryloxy group; C3 to C8 cycloalkyl group; C1 to C10 alkyl group substituted by 1, 2 or 3 heteroatoms; alkylaryl group including C1 to C10 alkyl group substituted by aromatic group and C1 to C10 alkyl group substituted by optionally 1 to 3 substituted aromatic groups including acyl group, —OCH2O—, halogen, haloalkyl group, hydroxyl group, aryl group, C3 to C8 cycloalkyl group, C1 to C10 alkyl group, acyloxy group, C1 to C10 alkoxy group; heteroarylalkyl group includes C1 to C10 alkoxy group substituted by heteroaryl group, and C1 to C10 alkyl group optionally substituted by any heteroaryl group including heteroaryl group, C1 to C10 alkyl group, aralkyl group, C3 to C8 cycloalkyl group, C1 to C10 alkoxycarbonyl group, carbamoyl group, aromatic group and C1 to C6 amide group; straight chain or branched C2 to C10 alkenyl group or alkenyl group containing optionally 1 to 3 substituted groups including oxygen group, halogen, aromatic ring group, aralkyl group, C1 to C10 alkoxy group, acyloxy group, amide group, C1 to C6 amine acyl group, C1 to C10 alkoxy group, aryloxy group, and C1 to C10 heteroalkyl group containing 1, 2 or 3 heteroatoms; C4 to C10 cycloalkenyl, C4 to C10 alkynyl group, or alkynyl group containing optionally 1 to 3 substituted groups including oxygen group, halogen, aromatic ring group, aralkyl group, C1 to C10 alkoxy group, acyloxy group, amide group, C1 to C6 acyl group, C1 to C10 alkoxy group, aryloxy group and C1 to C10 heteroalkyl group including 1, 2 or 3 heteroatoms; s and t are positive integers, and the sum of s and t is a natural number of 2 to 10; m is 0, 1, 2 or 3, and represents the number of the substituted group on R7 of the ring; n is 0, 1, 2 or 3, and represents the number of B on the ring; B is carbon, nitrogen or oxygen; B is carbon, the groups of R7, R8 are identical with the group of R5, or carbonyl group, imino group, oxime group, aliphatic group; or when B is tertiary nitrogen, R8 is oxygen, and so as to form nitrogen oxides with B; and, R4, R3, R2, R1 are not simultaneously hydrogen on the Formula (I). |
