PEPTIDE COMPOUNDS SUITABLE FOR USE AS ANTIBIOTIC AGENTS

摘要

The invention relates to compounds of formula (I), wherein R0 is a CH3-(CH2)m- radical, wherein m is an integer between 4 and 10; R1, R3, R4, R7 and R8 are independently selected radicals which have the following formula: GF-(CH2)n-; wherein n is an integer between 1 and 4; and GF is a radical selected among the group that consists of -NH2 and -NH-C(=NH)-NH2; R2 is a -CH(CH3)(OH), the CH of R2 being in either of the two configurations, R or S in the formula (I), giving rise to the corresponding epimers or to a mixture thereof; R5 is a -(CH2)-R10 radical; R6 is a straight or branched C4-alkyl radical; R9 is a radical selected among -CONH2 and -COOH; and R10 is a phenyl radical substituted with 1 to 5 identical substituents selected from the group that consists of F and (C1-C2)-alkyl, said compounds having been shown to be useful in the treatment of bacterial infections.