| 发明名称 |
Composition and method for diversification of target sequences |
| 摘要 |
The disclosure relates generally to the targeting of genes to, and their integration into, an innnnunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged V |
| 申请公布号 |
AU2013232114(A1) |
申请公布日期 |
2014.10.16 |
| 申请号 |
AU20130232114 |
申请日期 |
2013.03.13 |
| 申请人 |
OMEROS CORPORATION;UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION |
发明人 |
CUMMINGS, W. JASON;TJOELKER, LARRY W.;WOOD, CHRISTI L.;YABUKI, MUNEHISA;ALLISON, DANIEL S.;LEPPARD, JOHN B.;MAIZELS, NANCY |
| 分类号 |
C12N15/63;C12N15/13;C12N15/70;C12N15/79 |
主分类号 |
C12N15/63 |
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