| 摘要 |
The invention describes a pharmaceutical composition, comprising a mixture of carboxylated oligonucleotides, obtained by hydrolysis of natural polynucleotides, that results in oligonucleotide mixture, and carboxylation of purine nucleotide bases in the oligonucleotide mixture. The oligonucleotide mixture (DNA, RNA, or a combination of the two) of plant, animal, or fungal origin is conducted through chemical or biochemical enzymatic procedures, and then, a chemical modification of the oligonucleotides is provided, with carboxylation of their purine nucleotide bases through alkylation with monochloroacetic acid, or acylation with succinic anhydride. The pharmaceutical composition may be used in humans and animals for cancer treatment, immunodeficiency, viral infection diseases, etc. |
