发明名称 COMBINATION
摘要 The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.
申请公布号 US2014309243(A1) 申请公布日期 2014.10.16
申请号 US201414317775 申请日期 2014.06.27
申请人 GlaxoSmithKline LLC 发明人 DUMBLE Melissa;GILMER Tona;KUMAR Rakesh;LAQUERRE Sylvie;LEBOWITZ Peter F.;MORRIS Shannon Renae
分类号 A61K31/519;A61K31/4155 主分类号 A61K31/519
代理机构 代理人
主权项 1. A combination comprising: (i) a compound of Structure (I): or a pharmaceutically acceptable salt or solvate thereof; and (ii) a compound of Structure (II): or a pharmaceutically acceptable salt thereof.
地址 Wilmington DE US