METHODS FOR LUNG CANCER CLASSIFICATION

摘要

The present invention provides specific nucleic acid sequences for use in the identification, classification and diagnosis of various sub-types of lung cancers. The present invention permits one to accurately classify lung cancers based on their miR expression profile without further manipulation. Using microRNA microarray data generated from over two hundred formalin-fixed paraffin-embedded (FFPE) resection samples, fine needle aspiration (FNA) samples and fine needle biopsy (FNB) samples of primary lung cancer, microRNA expression profiles were identified that differ significantly for various sub-types of lung cancer.

主权项

1. A method for distinguishing between specific subtypes of lung cancer in a subject in need, the method comprising: obtaining a biological sample from said subject; determining an expression profile of at least one nucleic acid sequence selected from the group consisting of SEQ ID NOS: 1-8; a fragment thereof and a sequence having at least about 80% identity thereto in said sample; and comparing said expression profile to a reference expression profile; wherein the comparison of said expression profile to said reference expression profile is indicative of said lung cancer.