BIOMARKERS FOR T CELL MALIGNANCIES AND USES THEREOF

摘要

Described are biomarkers including TOX useful for the diagnosis or prognosis of T cell malignancy. A level of a biomarker is determined in a sample from a subject and compared to a control level, wherein an increased level of the biomarker in the sample relative to the control level indicates that the subject has T cell malignancy. The T cell malignancy may be a cutaneous T cell lymphoma (CTCL) such as mycosis fungoides or Sezary syndrome.

主权项

1. A method of screening for, diagnosing or detecting T cell malignancy in a subject, the method comprising:
(a) determining a level of TOX in a sample from the subject; and (b) comparing the level of TOX in sample to a control level, wherein an increased level of TOX in the sample relative to the control level indicates that the subject has T cell malignancy
wherein the T-cell malignancy is Cutaneous T-cell Lymphoma (CTCL), peripheral T-cell lymphoma or T cell leukemia.