发明名称 |
METHODS AND COMPOSITIONS OF TREATING AUTOIMMUNE DISEASES |
摘要 |
Embodiments of various aspects described herein are directed to methods and compositions for producing a tolerognic or immunosuppressive dendritic cell. In particular, an immunosuppressive dendritc cell can be produced by contacting a dendritic cell with an agent that stimulates the IL 27/ectonucleotidase CD39 axis signaling. In some embodiments, the methods and/or compositions described herein can be used for treating an autoimmune disease or disorder, e.g., but not limited to multiple sclerosis (MS) and type 1 diabetes. |
申请公布号 |
CA2918196(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
CA20142918196 |
申请日期 |
2014.04.11 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
QUINTANA, FRANCISCO J.;MASCANFRONI, IVAN D. |
分类号 |
C12N5/0784;A61K39/00;A61P37/06 |
主分类号 |
C12N5/0784 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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