发明名称 |
METHODS AND COMPOSITIONS FOR TREATING CANCER |
摘要 |
The invention is directed to methods, reagents, and kits for the detection of MAPK/ERK pathway mutations in a patient diagnosed for cancer. In one embodiment, the invention comprises a sensitive and selective method to identify mutations to the BRAF, KRAS, and NRAS genes in a single reaction. In another aspect of this embodiment, the invention comprises primers and probes for the detection of the BRAF, KRAS, and NRAS mutations using a single nucleotide primer extension assay. In another embodiment the invention is used to identify and select patients amenable for treatment with an ERK inhibitor. |
申请公布号 |
WO2014168801(A2) |
申请公布日期 |
2014.10.16 |
申请号 |
WO2014US32745 |
申请日期 |
2014.04.03 |
申请人 |
MERCK SHARP & DOHME CORP.;CHANG, KEN C. N.;GALUSKA, STEFAN;MARTON, MATTHEW, J. |
发明人 |
CHANG, KEN C. N.;GALUSKA, STEFAN;MARTON, MATTHEW, J. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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