发明名称 |
ANTIBODY AND METHODS FOR SELECTIVE INHIBITION OF T-CELL RESPONSES |
摘要 |
The present invention provides compositions, methods, and assays for treating an inflammatory and/or autoimmune disease, and/or transplanted tissue rejection using anti-α&bgr; TCR antibodies and antibody fragments. Anti-α&bgr; TCR antibodies are antibodies which bind to a α&bgr; TCR. Anti-α&bgr; TCR antibodies produced by the hybridomaTOL101 MCB are also provided. Methods for treatment of an inflammatory disease, an autoimmune disease and for tissue transplant rejection using therapeutic dosing regimen of anti-α&bgr; TCR antibodies and antibody fragments and for upregulating the numbers of Treg T-cells are also provided. |
申请公布号 |
WO2013067517(A3) |
申请公布日期 |
2014.10.16 |
申请号 |
WO2012US63583 |
申请日期 |
2012.11.05 |
申请人 |
TOLERA THERAPEUTICS, INC |
发明人 |
GETTS, DANIEL RICHARDT;HERRMANN, JAMES JOSEPH;PUISIS, JOHN JAMES;FOKTA, FRANK J. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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