METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES

摘要

Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

主权项

1. A compound of Formula I: wherein: R1 is C3-4alkyl, halo-C1-4alkyl, hydroxy-C1-4alkyl, or —C1-4alkyl-OR′, wherein R′ is an oxygen protecting group; and R2 and R3 are each independently hydrogen or halo; subject to the proviso that when one of R2 or R3 is ortho-fluoro, and the other is hydrogen, R1 is not —CH2F, or a salt thereof.