TRIFUNCTIONAL AND COMPLETELY CLEARABLE SPECIFIC TARGETING AGENTS AND METHODS THEREOF

摘要

The invention provides a novel trifunctional targeting construct and related compositions and methods that are useful in therapeutic, diagnostic (including imaging) of various biological and/or pathological conditions and diseases such as cancers and diabetes. The trifunctional targeting construct of the invention provides enhanced clearing step and reduced non-specific background via complete clearance of undesired antibody conjugates.

主权项

1. A conjugate compound comprising:
a targeting moiety capable of selectively binding to a primary and specific target site or to a substance produced by or associated with the target site; a first conjugate moiety comprising two covalently linked ligand groups, a first ligand group and a second ligand group; and a covalent linkage between the targeting moiety and the first conjugate to form a second-order conjugate compound.