发明名称 |
CRYSTAL OF PYRROLE DERIVATIVE AND METHOD FOR PRODUCING THE SAME |
摘要 |
Provided are an intermediate in the manufacture of an atropisomer of a dipyrromethene that has excellent mineralocorticoid receptor antagonism, a method for manufacturing the same and crystals thereof. A method for manufacturing an atropisomer of a dipyrromethene that includes the step of dividing the atropisomer of general formula (I) [In the formula, R1 is a methyl group or a trifluoromethyl group, R2 is a hydrogen atom or a C1-C3 alkoxy group, and n is an integer selected from 1 to 3.] characterized by using an optically active amine that has a cinchonan skeleton, and crystals of (S)-1-(2- hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-( trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide. |
申请公布号 |
CA2908879(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
CA20142908879 |
申请日期 |
2014.04.07 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
WATANABE, MASASHI;OKACHI, TAKAHIRO;KAWAHARA, MICHIAKI;NAGASAWA, HIROSHI;SATO, NORITADA;TAKITA, TAKASHI;HASEGAWA, GEN |
分类号 |
C07D207/34;A61K31/40;A61P43/00 |
主分类号 |
C07D207/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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