HLA-DR7 HY epitope and method for treating leukaemia

摘要

This invention concerns HY epitopic polypeptides specifically presented by the HLA-DR7 molecule, a method for preparing these epitopic polypeptides, isolated T-lymphocytes capable of specifically recognizing an epitope from these polypeptides or from a polypeptide comprising the complete sequence of the protein encoded by the RPS4Y gene and presented by the HLA-DR7 molecule expressed on the surface of antigen-presenting cells, a method for preparing these T-lymphocytes, as well as the use of these epitopic polypeptides and these T-lymphocytes as medicaments, in particular for the treatment of cancers of immune cells.

主权项

1. An isolated polypeptide comprising:
a) the TGKIINFIKFDTGNL sequence (SEQ ID NO: 1), or b) a peptide fragment of at least 9 consecutive amino acids of the sequence SEQ ID NO: 1 or c) a variant of the sequence SEQ ID NO: 1 or of a fragment according to b), differing from the sequence SEQ ID NO: 1 or from the fragment according to b) by conservative substitution of one, two or three amino acids, or d) a peptidomimetic of the sequence SEQ ID NO: 1 or of the fragment according to b) or of the variant according to c), said peptidomimetic being obtained by structural modification using unnatural amino acids, the said peptide fragment, the said peptidomimetic and the said variant having the capacity to activate T-lymphocytes when it is presented by the HLA-DR7 molecule;the said polypeptide comprising neither the complete sequence of the protein encoded by the RPS4Y gene, nor the TIRYPDPVI sequence (SEQ ID NO: 2), nor the VIKVNDTVQI sequence (SEQ ID NO: 3).