Modified antibody in which motif comprising cysteine residue is bound, modified antibody-drug conjugate comprising the modified antibody, and production method for same

摘要

The present invention concerns: an antibody in which a motif consisting of a peptide or an amino acid comprising one or more cysteine residues is bound to a terminal and more particularly a medium-chain terminal of the parent antibody; a modified antibody-drug conjugate (mADC, antibody-drug conjugate) in which the antibody and a drug are bound; and a production method for the antibody or the modified antibody-drug conjugate. The modified antibody-drug conjugate (mADC, antibody-drug conjugate) according to the present invention is highly specific to antigens of the antibody comprised in the conjugate and so can accurately deliver the drug to target cells and hence can increase the therapeutic effect and can also bring about greater utilisation of drugs and particularly anticancer drugs and the like of which use is limited due to toxicity despite being highly effective. Also, the present invention concerns a composition for treating diseases and particularly cancer by using the modified antibody-drug conjugate.