发明名称 |
ATOXIC RECOMBINANT HOLOTOXINS OF CLOSTRIDIUM DIFFICILE AS IMMUNOGENS |
摘要 |
Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system top develop a vaccine to reduce incidence and severity of C. difficile infection (CDI). Immunogens evaluated as potential vaccine candidates are mutated toxin A (encoded by TcdA) and toxin B (TcdB), and a rationally designed chimeric protein containing full-length TcdB protein except that the receptor binding domain is replaced with that of TcdA (designated as cTxAB). A small deletion (97 amino acids) in the transmembrane domain was used to reduce or eliminate toxicity. |
申请公布号 |
EP2519257(A4) |
申请公布日期 |
2014.10.15 |
申请号 |
EP20100835113 |
申请日期 |
2010.12.02 |
申请人 |
TUFTS UNIVERSITY |
发明人 |
FENG, HANPING;WANG, HAIYING;TZIPORI, SAUL |
分类号 |
A61K39/08;A61K35/74;A61P37/00;C07K14/33;C12N1/21 |
主分类号 |
A61K39/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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