发明名称 |
Sulfolobal Phosphotriesterase-Like (PLL) lactonases activity having enhanced properties and the uses thereof |
摘要 |
The present invention provides mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, said mutated PTE comprising the at least one mutation choosen amongst 53 putative positions and said mutated PTE having enhanced properties. Also provided are compositions comprising the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate. |
申请公布号 |
EP2789344(A1) |
申请公布日期 |
2014.10.15 |
申请号 |
EP20130305483 |
申请日期 |
2013.04.12 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITÉ D'AIX-MARSEILLE |
发明人 |
CHABRIERE, ERIC;ELIAS, MIKAEL;HIBLOT, JULIEN;RAOULT, DIDIER |
分类号 |
A61K38/46;C07K14/195;C12N9/16 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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