METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS
摘要
The present invention relates to a method for determining the sensitivity and/or resistance of a patient suffering from a cancer disease to Aurora kinase inhibitor therapy, which comprises determining in vitro in the cancer cells or body fluids taken from the patient the expression of at least one gene selected from a particular group and/or determining in vitro in the cancer cells or body fluids taken from the patient the level of at least one protein selected from a particular group. Also, the invention relates to a group of compounds which allow overcoming the resistance.
申请公布号
EP2788504(A2)
申请公布日期
2014.10.15
申请号
EP20120816228
申请日期
2012.12.07
申请人
PALACKY UNIVERSITY, OLOMOUC;INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS ASCR,V.V.I.
发明人
KOLLAREDY, MADHUSUDHAN REDDY;HAJDUCH, MARIAN;DZUBAK, PETR;SROVNAL, JOSEF;HRABAKOVA, RITA;KOVAROVA, HANA