| 发明名称 |
SUBSTITUTED PYRAZOLES AS MGLU5 RECEPTOR MODULATORS |
| 摘要 |
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description. |
| 申请公布号 |
EP2788086(A1) |
申请公布日期 |
2014.10.15 |
| 申请号 |
EP20120808705 |
申请日期 |
2012.12.05 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
GRAUERT, MATTHIAS;BISCHOFF, DANIEL;DAHMANN, GEORG;KUELZER, RAIMUND;RUDOLF, KLAUS;WELLENZOHN, BERND |
| 分类号 |
A61P25/00;A61K31/424;C07D231/12;C07D401/06;C07D401/14;C07D403/06;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D471/04;C07D487/04;C07D491/04;C07D495/04;C07D498/04 |
主分类号 |
A61P25/00 |
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