发明名称 |
BRANCHED ALKYL AND CYCLOALKYL TERMINATED BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS |
摘要 |
The present invention relates to a cationic lipid of formula (I) having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. |
申请公布号 |
EP2788316(A1) |
申请公布日期 |
2014.10.15 |
申请号 |
EP20120815878 |
申请日期 |
2012.12.07 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
ANSELL, STEVEN, MICHIAL;DU, XINYAO |
分类号 |
C07C217/08;C07C229/12 |
主分类号 |
C07C217/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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