DI-SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS

摘要

The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is—NH-G2-,—N(lower alkyl)-G2-,—NH—CH2-G2-,—N(lower alkyl)-CH2-G2- or—CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is—O-lower alkylene-R2 or the like; G4-O—is lower alkylene-O—or the like; G5 is lower alkylene; G6 is lower alkylene].