Gel-formulations of hydrophobic photosensitizers for mucosal applications

摘要

The present invention relates to improved methods of formulations of hydrophobic photosensitizers, and their precursors, for mucosal administration. The formulation of the invention comprises of hydrophobic photosensitizers which have been incorporated into suitably sized liposomes. Additionally, these formulations include the incorporation of PS-loaded liposomes into a copolymer matrix. The liposome of the present invention allows the hydrophobic photosensitizers to be incorporated into the thermogel matrix and thus promoting intimate contact between the formulation and the mucosal layer for enhanced drug absorption.

主权项

1. A chemical composition formulation for the delivery of a hydrophobic drug across a mucus coated membrane, consisting of (a) a lipid soluble, hydrophobic photosensitizer or a lipid soluble, hydrophobic photosensitizer precursor, (b) a liposomal vesicle, and (c) a mucoadhesant; wherein said liposomal vesicle is based on phospholipids and said mucoadhesant comprises at least one copolymer.