Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications

摘要

The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre-m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.

主权项

1. A recombinant measles virus, comprising a polynucleotide coding for a polypeptide which is the West-Nile virus (WNV) secreted envelope glycoprotein (sE) of SEQ ID NO: 5;
wherein the recombinant measles virus is a live attenuated measles virus; and wherein the recombinant measles virus induces an immune response that limits growth and spread of an infectious WNV when administered to an animal.