ANTIDEPRESSANT, NEUROPROTECTANT, AMYLOID .BETA. DEPOSITION INHIBITOR OR AGE RETARDANT CONTAINING HETEROCYCLIC COMPOUND HAVING SPECIFIC STRUCTURE

摘要

The present invention provides an antidepressant, neuroprotectant, amyloid .beta. deposition inhibitor, or age retardant composition comprising containing a heterocyclic compound having the general Formula (I): (see formula I) .. or a pharmaceutically acceptable salt or hydrate thereof. The structural unit (see formula II) being selected from (see formulas III) R1 and R2 each are one or more functional groups independently selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, amino group, acetylamino group, benzylamino group, trifluoromethyl group, C1-C6 alkyl group, C1-C6 alkoxy group, and -O-(CH2)n-R3, wherein R5 is a vinyl group, C3-C6 cycloalkyl group, or phenyl group, and n is 0 or 1. R3 and R4 together form a spiro ring B of the general formula (IV): (see formula IV) The spiro ring B is a structural unit having the general Formula (V) and binds at a position marked by *in the general Formulas (V) to form a spiro ring. (see formula V) ....................................... R8 is one or more functional groups selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, C1-C6 alkoxy group, cyano group, and trifluoromethyl group.