Analyte screening and detection systems and methods

摘要

Methods of concentrating an analyte that is in liquid and method of detecting an analyte in a liquid are disclosed. Methods of screening a liquid for the presence of an analyte are also disclosed. Processes comprising continuously collecting a sample of fluid throughout the process and analyzing the sample are disclosed as are processes comprising treating ultrafilter membranes. Devices and systems for concentrating an analyte that is in liquid and for screening a liquid for an analyte are disclosed as well as devices and systems for concentrating an analyte from a continuous sample are disclosed.

主权项

1. A method of concentrating an analyte that is in liquid comprising:
a) forming a retentate that contains an analyte by passing a liquid that contains an analyte through a stage 1 ultrafilter membrane that the analyte cannot pass through, wherein the stage 1 ultrafilter membrane has a retentate side on which the liquid that contains the analyte is contacted and a permeate side from which a filtrate exits upon passing through the stage 1 ultrafilter membrane; and, b) collecting the retentate by
i) displacing filtrate from the permeate side of the stage 1 ultrafilter membrane with a gas to remove liquid and introduce gas into the permeate side prior to collecting retentate, andii) collecting retentate by flushing the retentate side of the stage 1 ultrafilter membrane with gas and with liquid to produce a retentate solution that comprises the retentate, andiii) collecting the retentate solution.