Active transdermal medicament patch and circuit board for same

摘要

An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.

主权项

1. A transdermal medicament patch comprising:
(a) a flexible, planar biocompatible substrate having on one side thereof an upper face and on the other side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a circuit board carried on said upper face of said substrate, said circuit board having on one side thereof a support face and on the other side thereof an attachment face, a portion of said attachment face of said circuit board being non-removably secured to said upper face of said substrate; (c) a printed circuit on said support face of said circuit board; (d) a power source mounted directly on said support face of said circuit board; (e) an electrode carried on said support face of said circuit board, said electrode being electrically coupled to said power source by said printed circuit; and (f) an electrode hinge traversing said circuit board intermediate said electrode and said power source for permitting bending of said circuit board between:
(i) a planar state of said circuit board; and(ii) a compact state of said circuit board, wherein a portion of said circuit board is folded over such that two portions of said circuit board are in planar contact with each other, wherein in said compact state of said circuit board, the periphery of said circuit board assumes the shape of a barbell, said barbell having enlarged ends interconnected by an intermediate portion narrower in extent than the ends.